Gene Variants And Health

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Genetic variation across and within individuals - Nature

(Just Now) WEBGenetic variation across and within individuals is a dynamic mosaic of germline and somatic variants that can influence one another to shape health and …

https://www.nature.com/articles/s41576-024-00709-x

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Gene–environment interactions and their impact on …

(Just Now) WEBGenetic etiology of disease. In many cases, genetic variants impact phenotypes that contribute to disease pathology. Historically, family studies have been …

https://www.nature.com/articles/s41435-022-00192-6

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Human genetic variants identified that affect COVID

(Just Now) WEBMoreover, human genetic variants usually have relatively small effects on infection outcomes compared with the effects of socio-demographic factors such as age or access to health care 8

https://www.nature.com/articles/d41586-021-01773-7

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ClinVar - National Center for Biotechnology Information

(7 days ago) WEBIf you have questions about the information contained on this website, please see a health care professional. More information about NCBI's disclaimer policy is available. National …

https://www.ncbi.nlm.nih.gov/clinvar/

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Clinical Interpretation and Management of Genetic Variants

(3 days ago) WEBGenetic variants located in deep intronic (other than the canonical splice sites) and intergenic regions are the most abundant SNVs, totaling ∼4 million in each …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591931/

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Nine billion and counting - Mapping the human variants and their

(3 days ago) WEBThe Atlas of Variants Effects Alliance (AVE) is an international collaborative project with the aim of creating an atlas and assessing the effects of all the possible …

https://sangerinstitute.blog/2024/01/16/nine-billion-and-counting-mapping-the-human-variants-and-their-effects-on-health-and-disease/

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Gene–environment interactions and their impact on …

(3 days ago) WEBGene × environment interactions. While genetic and environmental factors can independently increase the risk of disease, the interactions between these risk …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801363/

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275 million new genetic variants identified in NIH precision …

(Just Now) WEBMonday, February 19, 2024. Credit: NIH/All of Us Research Program. Researchers have discovered more than 275 million previously unreported genetic variants, identified …

https://www.nccih.nih.gov/news/press-releases/275-million-new-genetic-variants-identified-in-nih-precision-medicine-data

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NIH programs shed light on gene variants and their connections …

(6 days ago) WEBPrograms supported by the National Institutes of Health are establishing which genes and genomic variants play a role in human disease, enabling their use in …

https://www.nih.gov/news-events/news-releases/nih-programs-shed-light-gene-variants-their-connections-health-disease

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A Healthy Lifestyle Can Add Years to Life, Despite 'Bad' Genes

(3 days ago) WEBThe score combines multiple changes in DNA (known as variants) that influence life expectancy. Li said using this tool with screening and genetic counseling …

https://www.webmd.com/balance/news/20240509/defeat-bad-genes-with-healthy-lifestyle

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Study defines major genetic form of Alzheimer’s disease

(5 days ago) WEBA small portion of early-onset Alzheimer’s disease (AD) cases are known to be genetically determined. These include early-onset autosomal dominant AD and Down …

https://www.nih.gov/news-events/nih-research-matters/study-defines-major-genetic-form-alzheimer-s-disease

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Almost All People With Two Copies of This Genetic Variant …

(6 days ago) WEBA number of genetic variants, including APOE4, have been tied to an increased risk for the disease. But with the new paper, researchers suggest having two copies of the APOE4 …

https://www.msn.com/en-us/health/other/almost-all-people-with-two-copies-of-this-genetic-variant-develop-signs-of-alzheimers-disease-study-finds/ar-BB1lZzEO

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Researchers show genetic variant common among Black …

(2 days ago) WEBResearchers at Brigham and Women's Hospital and Duke University showed that a genetic variant, present in 3-4% of self-identified Black individuals in the U.S., …

https://medicalxpress.com/news/2024-05-genetic-variant-common-black-americans.html

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Characterizing the pathogenicity of genetic variants: the - Nature

(Just Now) WEBRegulatory processes, genetic buffering, environmental interactions, and epistasis can all play roles in determining the impact of a given variant 16,17,18,19, and …

https://www.nature.com/articles/s41525-023-00386-5

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What to Know About New Covid Variants, ‘FLiRT’: Symptoms, …

(4 days ago) WEBExperts are closely watching KP.2, now the leading variant. By Dani Blum For most of this year, the JN.1 variant of the coronavirus accounted for an overwhelming …

https://www.nytimes.com/2024/05/10/well/covid-flirt-variants-symptoms.html

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Genetic variant common among West African descendants …

(Just Now) WEBUsing this large dataset, the researchers analyzed data from 23,338 self-reported Black individuals, out of whom 754, or a little over 3% of them, carried the …

https://www.statnews.com/2024/05/13/genetic-variant-west-african-descendants-adds-cardiovascular-disease-risk/

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Scientists restore brain cells impaired by a rare genetic disorder

(8 days ago) WEBScientists restore impaired brain cells in Timothy syndrome patients : Shots - Health News A therapy that restores brain cells impaired by a rare genetic disorder may …

https://www.npr.org/sections/health-shots/2024/04/30/1247900797/timothy-syndrome-genetic-disorder-brain-cells-restored

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Genetics and Health - Genes, Behavior, and the Social Environment

(4 days ago) WEB3. Genetics and Health. Although there are many possible causes of human disease, family history is often one of the strongest risk factors for common disease …

https://www.ncbi.nlm.nih.gov/books/NBK19932/

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Researchers find gene that may put Black Americans at higher risk …

(4 days ago) WEBResearchers at Brigham and Women's Hospital and Duke University pooled data from four NIH-funded studies and found that a genetic variant, found in 3% to 4% …

https://www.cbsnews.com/boston/news/brigham-and-womens-hospital-black-americans-heart-failure/

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New COVID variants FLiRT: Details on symptoms, possible summer …

(3 days ago) WEB"The CDC is tracking SARS-CoV-2 variants KP.2 and KP.1.1, sometimes referred to as 'FLiRT,' and working to better understand their potential impact on public …

https://www.usatoday.com/story/news/health/2024/05/15/new-covid-variants-flirt-symptoms-summer-surge/73697570007/

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What to Know About COVID FLiRT Variants Johns Hopkins

(3 days ago) WEBAt the end of March, the KP.2 variant was causing about 4% of infections in the U.S., according to the CDC, while its parental strain, JN.1, was causing over 50% of …

https://publichealth.jhu.edu/2024/what-to-know-about-covid-flirt-variants

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Genetic analyses reveal new viruses on the horizon - Phys.org

(4 days ago) WEBSuddenly they appear, and like the SARS-CoV-2 coronavirus, can trigger major epidemics: Viruses that nobody had on their radar. They are not really new, but …

https://phys.org/news/2024-05-genetic-analyses-reveal-viruses-horizon.html

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First Patient Begins Newly Approved Sickle Cell Gene Therapy

(9 days ago) WEBKendric Cromer, 12, the first commercial patient for Bluebird Bio’s gene therapy to cure his sickle cell disease, in the hospital as his bone marrow stem cells …

https://www.nytimes.com/2024/05/06/health/sickle-cell-cure-first.html

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Mega study charts how genetic variants affect metabolism - Nature

(Just Now) WEBWe also observed genetic pleiotropy — a phenomenon in which the same genetic variant affects multiple metabolic processes — across lipid, lipoprotein and …

https://www.nature.com/articles/d41586-024-00458-1

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Experimental gene therapy restores some vision in patients with

(1 days ago) WEBAmong a total of 14 volunteers, including Cook, the gene-editing tool was found to be associated with a “meaningful improvement” in vision for most patients …

https://www.cnn.com/2024/05/06/health/gene-editing-blindness-study-scn/index.html

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Genetic Variation, Comparative Genomics, and the Diagnosis of …

(3 days ago) WEBThe discovery of mutations associated with human genetic disease is an exercise in comparative genomics (see Glossary). Although there are many different …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681822/

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Omicron variant: NJ has first confirmed case of COVID strain

(9 days ago) WEBNew Jersey has identified its first case of the COVID-19 omicron variant, state officials said late Friday. The case was traced to a Georgia woman who traveled to …

https://www.northjersey.com/story/news/coronavirus/2021/12/03/omicron-variant-nj-first-case-covid/8860381002/

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Common Gene Variant Drives Weight Gain Integrative Medicine …

(3 days ago) WEBCommon Gene Variant Drives Weight Gain. One in two people have a gene variation that drives overeating; healthy lifestyles blunt the effects. More than one-third of American …

http://integrativemedicineofnj.com/common-gene-variant-drives-weight-gain

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New COVID variant BA.2 has New Jersey case numbers rising

(Just Now) WEBBA.2 made up 84% of all COVID strains in New Jersey and New York on April 2, up from 39% on March 12, according to data released this week by the Centers for …

https://www.northjersey.com/story/news/coronavirus/2022/04/08/new-covid-variant-ba-2-new-jersey-case-numbers/7232272001/

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Five steps to connect genetic risk variants to disease - Nature

(Just Now) WEBOur Variant-to-Gene-to-Program (V2G2P) approach consists of five steps. In step one, we choose a cell type relevant to disease. In steps two and three, we use …

https://www.nature.com/articles/d41586-024-00061-4

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Participants of pioneering CRISPR gene editing trial see vision …

(4 days ago) WEB“This trial shows CRISPR gene editing has exciting potential to treat inherited retinal degeneration,” said Mark Pennesi, M.D., Ph.D., a corresponding author on the …

https://news.ohsu.edu/2024/05/06/participants-of-pioneering-crispr-gene-editing-trial-see-vision-improve

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