Rethinkingclinicaltrials.org

NIH Collaboratory Rethinking Clinical Trials – The Living Textbook

WebWelcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present …

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URL: https://rethinkingclinicaltrials.org/

Learning Healthcare Systems

WebA learning healthcare system is [one that] is designed to generate and apply the best evidence for the collaborative healthcare choices of each patient and provider; to drive …

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Electronic Health Records

WebElectronic Health Records (EHR) Core members have expertise in: The secondary use of EHR data for clinical research requires an understanding of data representation, …

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About NIH Collaboratory

WebTo accomplish this vision, the NIH Pragmatic Trials Collaboratory plans to: Create a new infrastructure for collaborative research with healthcare systems partners. Generate …

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Dissemination to Healthcare System Leaders

WebExample activities for planning for impact: Identify why the study findings will matter to health system leaders, whether findings are positive or negative. Identify other partners, …

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How Are PRO Measures Used

WebPRO Measures as Monitoring Tools (Adverse Events and Symptoms) PRO measures can also be used to capture or monitor the adverse effects of an intervention separately from …

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Evaluating Phenotype Definitions

WebThe Electronic Health Records Core Working Group (formerly the Phenotypes, Data Standards, and Data Quality Core Working Group) of the NIH Collaboratory influenced …

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Interoperability

WebInteroperability between electronic health record systems has the potential to benefit patients, payers, health systems, researchers, and clinicians because it would enable …

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Opportunities in mHealth

WebOpportunities in mHealth. Digital health is a broad, inclusive term referring to the use of digital technology to improve health services, health research, or health outcomes. …

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February 7, 2020: Using Nudges to Improve the Delivery of Health …

WebFebruary 7, 2020: Using Nudges to Improve the Delivery of Health Care (Mitesh S. Patel, MD, MBA)

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Electronic Health Record Data Extraction

WebElectronic Health Record Data Extraction. Many pragmatic clinical trials, whether designed as cluster randomized trials or as individually randomized trials, rely on data extraction …

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Intervention Adaptation Strategies and Examples

WebCommon Strategies to Anticipate Changes and Monitor Adherence and Adaptations. Build and nurture relationships with health system partners. Consider using …

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Cultural Adaptation and Linguistic Translation

WebCultural adaptation: Adapting an existing instrument to measure a phenomenon in a different culture. Linguistic adaptation: Translating an existing instrument to measure a …

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The Embedded Pragmatic Clinical Trial Ecosystem

WebDefinition of a Pragmatic Clinical Trial. According to Califf and Sugarman, there are “three key attributes of PCTs: (1) an intent to inform decision-makers (patients, clinicians, …

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Case Example From the Nudge Study

WebThe objectives of the Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (Nudge) study, a two-part, …

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