Pathsocjournals.onlinelibrary.wiley.com
Skin fibroblast functional heterogeneity in health and disease
WEBA key challenge in the field is to understand the functional relevance and significance of the identified new cell clusters in health and disease. Here, we discuss the functionally distinct fibroblast subtypes identified in skin homeostasis and repair and how they evolve in fibrotic disease conditions, in particular keloid scars and cancer
Actived: 9 days ago
URL: https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6159
PINK1 in the limelight: multiple functions of an eclectic protein in
WEBPINK1 functions in health and disease PINK1 and neurodegeneration Parkinson's disease (PD) is one of the commonest neurodegenerative disorders, affecting more than 1% of the population over 60 years; its motor phenotype, characterized by bradykinesia, rigidity, resting tremor, and postural instability, reflects the progressive loss …
The fifth edition of the WHO classification of mature B‐cell …
WEBThe fifth edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) is the product of an evidence-based evolution of the revised fourth edition with wide multidisciplinary consultation. Nonetheless, while every classification incorporates scientific advances and aims to improve upon the prior …
The roles of fascins in health and disease
WEBIntroduction: fascin structure, gene family, and evolution. Fascins are globular proteins of approximately 55 kD composed of four tandem fascin domains, each of which corresponds structurally to a β-trefoil fold 1, 2.Related fascin domain proteins include Dictyostelium hisactophilin, a pH-regulated actin-binding protein with a single β-trefoil …
The use of digital pathology and image analysis in clinical trials
WEBThe Health Research Authority (HRA) have recently updated their guidance on approval of new medical devices including software applications. The use of diagnostic platforms would require dedicated medical device clinical evaluation studies to obtain HRA approval, which would entail using systems in parallel with standard practice using light
The Journal of Pathology
WEBAnother area important in fibrosis in health and disease is the role of TGF-β, the major profibrotic cytokine. The article by Rik Derynck and colleagues focuses on the roles of increased TGF-β activities and the underlying signalling mechanisms in activated fibroblasts and other cell types during fibrosis. As a universal driver of fibrosis
Computational pathology in cancer diagnosis, prognosis, and …
WEBIBEX Galen (Tel Aviv, Israel) was recently awarded the Artificial Intelligence in Health and Care Award and will begin deploying their Galen Breast product in October 2023 to assess over 10,000 biopsies as part of routine practice across five NHS trusts in the Midlands (UK). Nevertheless, as of April 2023, the FDA had approved fewer than ten AI
the under-recognized element in lung disease
WEBLung-resident fibroblasts contribute greatly to the ECM in health, and are able to differentiate into muscle-like contractile myofibroblasts, adopt a migratory phenotype, or proliferate in response to injury cues 55-57. Myofibroblasts deposit collagen types I and III during fibrotic events, but also collagen type IV, various PGs, and
Anoikis: an emerging hallmark in health and diseases
WEBIntrinsic pathway. In the intrinsic pathway, caspase activation occurs as a consequence of mitochondrial permeabilization due to formation of oligomers in the outer mitochondrial membrane (OMM) by the pro-apoptotic proteins of the Bcl-2 family, thereby creating channels and causing membrane permeabilization 7, 8.An adjuvant role of the …
The systemic influence of chronic smoking on skin structure and
WEBIncreased public health awareness of the positive effects of stopping smoking and maintaining abstinence on both facial appearance and respiratory health should be encouraged. In conclusion, we identified a significant remodelling of the cutaneous elastic fibre system in smokers. This remodelling, which appears to be …
The pathogenesis of syphilis: the Great Mimicker, revisited
WEBIt is more common among the poor, those who lack access to health care, and in those with many sexual partners. The WHO has estimated that 12 million new cases of venereal syphilis occurred in 1999, most of them in developing countries 13 (Figure 1). Congenital syphilis remains a leading cause of perinatal and neonatal deaths in many …
Recent Advances in Pathology: the 2023 Annual Review Issue of
WEBThe 2023 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 12 invited reviews on topics of current interest in pathology.This year, our subjects include immuno-oncology and computational pathology approaches for diagnostic and research applications in human disease.
Recent Advances in Pathology: the 2022 Annual Review Issue of …
WEBBy combining established concepts with recent advances, the article provides an up-to-date view of the complexity of proteolysis regulation and signalling pathways in epidermal health and disease. The final article in this issue deals with the concept of field cancerisation in breast as an explanation for tumour recurrence, which …
Advancing drug discovery using the power of the human genome
WEBHuman genetics plays an increasingly important role in drug development and population health. Here we review the history of human genetics in the context of accelerating the discovery of therapies, present examples of how human genetics evidence supports successful drug targets, and discuss how polygenic risk scores could be beneficial in …
The Journal of Pathology: Vol 257, No 4
WEBBeyond the snapshot: optimizing prognostication and prediction by moving from fixed to functional multidimensional cancer pathology. CJH Kramer, MPG Vreeswijk, B Thijssen, T Bosse, J Wesseling. , Pages: 403-412. First Published: 19 April 2022. Abstract.
Anoikis: an emerging hallmark in health and diseases
WEBAbstract. Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix. Anoikis prevents detached epithelial cells from colonizing elsewhere and is thus essential
Recent Advances in Pathology: the 2020 Annual Review Issue of …
WEBRecent advances in epigenetics and non-coding RNAs in health and disease. The first article in this section discusses the current thinking on long non-coding RNAs (lncRNAs) and their roles in development and disease. Julie Aspden and colleagues firstly provide a definition for lncRNAs and discuss the different categories of lncRNAs …
The endocrine system and ageing
WEBAbstract. Complex changes occur within the endocrine system of ageing individuals. This article explores the changes that occur in the metabolism and production of various hormones and discusses the resulting clinical consequences. As individuals age there is a decline in the peripheral levels of oestrogen and testosterone, with an increase …
Molecular breakdown: a comprehensive view of anaplastic …
WEBDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University School of Medicine, Seoul, Korea. Laboratory of Cancer Genomics and Molecular Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Search for more papers by this author
Critical role for iron accumulation in the pathogenesis of fibrotic
WEBIncreased iron levels and dysregulated iron homeostasis, or both, occur in several lung diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis and associated lung function decline was investigated using a combination of murine models of iron overload and bleomycin-induced pulmonary …
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