Journals.biologists.com

Neurodegenerative disease: models, mechanisms, and a new hope

WEBNeurodegenerative diseases represent a major threat to human health. These age-dependent disorders are becoming increasingly prevalent, in part because …

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URL: https://journals.biologists.com/dmm/article/10/5/499/2428/Neurodegenerative-disease-models-mechanisms-and-a

Disease Models & Mechanisms The Company of Biologists

WEBDisease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease. …

Category: Medical Go Health

The bone marrow microenvironment in health and disease at a …

WEBThe adult hematopoietic system, predominantly located in the bone marrow, is the most widely studied adult stem cell system (see poster). Our understanding of this …

Category: Health Go Health

Membrane trafficking in health and disease Disease Models

WEBMembrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a …

Category: Health Go Health

Skeletal muscle in health and disease

WEBSkeletal muscle is composed of linear arrays of multinucleated muscle fibres, each with a complex internal structure dedicated to the conversion of chemical to …

Category: Health Go Health

The origins and evolution of sleep

WEBLarge differences in sleep duration and timing among humans suggests that existing genetic variation among individuals potently affects sleep (Hartmann, 1973; …

Category: Health Go Health

A comprehensive definition for metabolic syndrome

WEBThe metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic …

Category: Health Go Health

Muscles and their myokines

WEBSummaryIn the past, the role of physical activity as a life-style modulating factor has been considered as that of a tool to balance energy intake. Although it is …

Category: Health Go Health

p62/SQSTM1 – steering the cell through health and disease

WEBSQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold protein involved in diverse cellular processes. Its functions are tightly regulated through …

Category: Health Go Health

Human haematopoietic stem cell development: from the embryo …

WEBOur current understanding of the mechanisms that drive HSC development has come from analysis of various model organisms. We do not intend here to provide …

Category: Health Go Health

Molecular and cellular mechanisms of tooth development, …

WEBOwing to its easy accessibility in the oral cavity and to the wide availability of relevant mutant and transgenic animal lines, the tooth provides a superb system to study …

Category: Health Go Health

Development The Company of Biologists

WEBDevelopment is a leading primary research journal covering the field of developmental biology. With its long and prestigious history and its team of expert academic editors, …

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Accessible analysis of longitudinal data with linear mixed effects

WEBLongitudinal studies are often used in biomedical research to improve our understanding of human conditions. Common applications for mouse models in …

Category: Medical Go Health

Distinct features of the regenerating heart uncovered through

WEBZebrafish have emerged as a powerful model for studying adult heart regeneration (González-Rosa et al., 2017; Poss et al., 2002).Experimentally induced …

Category: Health Go Health

Gene editing in human development: ethical concerns and …

WEBThe first report of gene editing directly in human embryos was published in March 2015. Although the study was carried out in non-viable tripronuclear embryos and …

Category: Health Go Health

GATA transcription factors in development and disease

WEBGATA transcription factors are evolutionarily conserved among animals, plants and fungi. Vertebrates possess six paralogs, classified into two subfamilies based …

Category: Health Go Health

On muscle, tendon and high heels

WEBSUMMARYWearing high heels (HH) places the calf muscle–tendon unit (MTU) in a shortened position. As muscles and tendons are highly malleable tissues, …

Category: Health Go Health

ALDH2 variance in disease and populations

WEBThe ALDH2*2 missense variant that commonly causes alcohol flushing reactions is the single genetic polymorphism associated with the largest number of traits …

Category: Health Go Health

The good, the bad and the slimy: experimental studies of hagfish

WEBEvery aspect of an animal's biology is shaped either directly or indirectly by the processes of feeding, digestion and nutrient assimilation. Ecological niche, intra- and …

Category: Health Go Health

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