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Determinants of body fat distribution in humans may …

WEBObesity increases the risks of developing cardiovascular and metabolic diseases and degrades quality of life, ultimately increasing the risk of death. However, not all forms of …

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URL: https://www.jlr.org/article/S0022-2275(20)32303-8/fulltext

From NAFLD to MASLD: updated naming and diagnosis …

WEBMetabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is a prevalent chronic liver disease worldwide, …

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Vitamin E in the prevention of cardiovascular disease: the …

WEBVitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. …

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Effects of oils and solid fats on blood lipids: a systematic …

WEBThe aim of this network meta-analysis (NMA) is to compare the effects of different oils/solid fats on blood lipids. Literature searches were performed until March 2018. Inclusion …

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25-Hydroxycholesterol in health and diseases

WEBCholesterol is an essential structural component of all membranes of mammalian cells where it plays a fundamental role not only in cellular architecture, but …

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Are BMI and other anthropometric measures appropriate …

WEBWe have examined the relationships between percentage of body fat (PBF) and risk factors for cardiovascular disease and insulin resistance and how good body mass index (BMI) …

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Home Page: Journal of Lipid Research

WEBThe Journal of Lipid Research focuses on the science of lipids in health and disease. The journal emphasizes lipid function and the biochemical and genetic regulation of lipid …

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Clinical lipidomics: realizing the potential of lipid profiling

WEBDysregulation of lipid metabolism plays a major role in the etiology and sequelae of inflammatory disorders, cardiometabolic and neurological diseases, and several forms of …

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THE CORONARY PRIMARY PREVENTION TRIAL

WEBAs of the early 1980s, despite the wealth of evidence from experimental animal models, the extensive epidemiologic evidence, the powerful genetic evidence, and the strongly …

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The medicinal plant goldenseal is a natural LDL-lowering …

WEBOur previous studies have identified berberine (BBR), an alkaloid isolated from the Chinese herb huanglian, as a unique cholesterol-lowering drug that upregulates hepatic low …

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Cholesterol sulfate in human physiology: what's it all about

WEBCholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant …

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Phosphatidylinositol increases HDL-C levels in humans

WEBPI significantly affected the levels of HDL-C and triglyceride in the plasma of subjects receiving PI with food. The lower dose showed a 13% increase in HDL-C, whereas the …

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Phosphoinositide-specific phospholipase C in health and disease

WEBPhospholipases are widely occurring and can be found in several different organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) is a class …

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Lipids and lipid metabolism in the eye

WEBThe vertebrate eye is a complex sensory organ consisting of multiple, distinct tissues, each having its own unique biochemical composition, structure, and physiological function. Key among these are the retina, lens, and cornea, working in concert to bring photons of light into the eye, focus them correctly on the retina, and convert their energy into …

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Dietary inulin decreases circulating ceramides by suppressing …

WEBElevated circulating levels of ceramides (Cers) are associated with increased risk of cardiometabolic diseases, and Cers may play a causative role in metabolic dysfunction …

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Dietary sphinganine is selectively assimilated by members of the

WEBFunctions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome …

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Roles of polyunsaturated fatty acids, from mediators to membranes

WEBPUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a …

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The role of short-chain fatty acids in the interplay between diet, …

WEBShort-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on …

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Cyclooxygenases: structural and functional insights

WEBCyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and …

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