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The impact of genomics on precision public health: beyond the …

WebThe field of precision public health is still in its infancy and genomics will be a major contributor to its growth in the next decade. The COVID-19 pandemic provides …

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URL: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00886-y

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WebGenome Medicine publishes important advances of broad interest in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease.The …

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Translating the human microbiome: a path to improving health

Web14 Altmetric. Metrics. Translating the human microbiome in health and disease requires detailed information about each microbial member—from individual …

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Dietary fiber intake, the gut microbiome, and chronic systemic

WebThe Health Professionals Follow-Up Study (HPFS) is an ongoing prospective cohort study of 51,529 US male health professionals aged 40 to 75 years at enrollment …

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Illuminating the human virome in health and disease

WebAlthough the microbiome is established as an important regulator of health and disease, the role of viruses that inhabit asymptomatic humans (collectively, the …

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The healthy human microbiome Genome Medicine Full Text

WebHumans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human …

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The Human Genome Project: big science transforms biology and …

WebThe Human Genome Project (HGP) has profoundly changed biology and is rapidly catalyzing a transformation of medicine [1–3].The idea of the HGP was first …

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Gut microbiome-host interactions in health and disease

WebThe human intestine carries a vast and diverse microbial ecosystem that has co-evolved with our species and is essential for human health [1, 2].Mammals possess …

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The microbiome in precision medicine: the way forward

WebNovel associations between the human microbiome and health and disease are routinely emerging, and important host–microbiome interactions are targets for new …

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Developmental origins of health and disease: reducing the burden …

WebDespite a wealth of underpinning experimental support, there has been considerable resistance to the concept that environmental factors acting early in life …

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Causality in dietary interventions—building a case for gut …

WebCausality is the missing link in our understanding of the gut microbiome, nutrition, and health. The gut microbiome has been at the forefront of medical research …

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Family history assessment significantly enhances delivery of …

WebFamily history has traditionally been an essential part of clinical care to assess health risks. However, declining sequencing costs have precipitated a shift towards …

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Microbial genomics: an increasingly revealing interface in human …

WebThe interactions may in fact be even more complex, as shown in a recent study of autoimmune diabetes in which a distinct blurring between pathogen and …

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Patient engagement as a risk factor in personalized health care: a

WebImproved models for the delivery of health care in the United States are greatly needed given that more than three-fourths of healthcare expenditures account for …

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Making sense of big data in health research: Towards an EU action …

WebOn 30 October 2015, the Health Directorate of the Directorate-General for Research and Innovation at the European Commission (EC), the executive body of the …

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Genomics of circadian rhythms in health and disease

WebCircadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects …

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Leveraging genomic diversity for discovery in an electronic health

WebLarge medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry …

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Systems medicine: the future of medical genomics and healthcare

WebHigh-throughput technologies for DNA sequencing and for analyses of transcriptomes, proteomes and metabolomes have provided the foundations for …

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Targeting the microbiome: from probiotics to fecal microbiota

WebThe notion of “good microbes” that may benefit host health originated in the early twentieth century when live microbes contained in fermented foods were thought to …

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Metagenomics for pathogen detection in public health

WebTraditional pathogen detection methods in public health infectious disease surveillance rely upon the identification of agents that are already known to be …

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